Antimicrobial Efficacy of Sevoflurane in Infected Wounds

Zeynep Cengiz; Ali Belge; Zeynep Bozkan Ünal; Hafize Tuğba Yüksel Dolgun; Büşra Kibar

doi:10.71336/ijvar.702

Authors

Zeynep Cengiz Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Surgery, Aydın, Türkiye
Ali Belge Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Surgery, Aydın, Türkiye
Zeynep Bozkan Ünal Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Surgery, Aydın, Türkiye
Hafize Tuğba Yüksel Dolgun Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Microbiology, Aydın, Türkiye
Büşra Kibar Aydın Adnan Menderes University, Faculty of Veterinary Medicine, Department of Surgery, Aydın, Türkiye

DOI:

https://doi.org/10.71336/ijvar.702

Keywords:

Antimicrobial activity, Skin lesions, Methicillin-resistant, Staphylococcus aureus, Topical sevoflurane

Abstract

The aim of this study was to investigate the antimicrobial efficacy of sevoflurane in wounds infected with Staphylococcus aureus, a species known for rapid antibiotic resistance. The study material was formed of 80 healthy, male Sprague-Dawley rats. A wound was created in each animal, and then infected with methicillin-sensitive Staphyloccocus aureus and with methicillin-resistant Staphyloccocus aureus. Isotonic sodium chloride, hypochlorous acid and liquid sevoflurane were applied to the wounds. Our results show that sevoflurane exhibited greater antimicrobial efficacy than both hypochlorous acid and isotonic sodium chloride in wounds infected with Staphyloccocus aureus. Therefore, topical use of sevoflurane could be considered a viable alternative, particularly for methicillin-resistant Staphyloccocus aureus infections. The wound healing with topical liquid sevoflurane was also seen to be more rapid than those with hypochlorous acid and isotonic sodium chloride.

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